The new equipment system allows a large variety of upgrades and customization for weapons and armor. The game also is the first in the series to feature full voice acting for the protagonist.

In addition, the game has new features, including developing and maintaining settlements and an extensive crafting system where drugs and explosives are crafted from materials scavenged from the environment.

The game explores the dilapidated world, completing various quests and acquiring experience points to level up and increase their character’s abilities.